The gut microbiota plays a pivotal role in many aspects of human health and modulates susceptibility to a wide spectrum of diseases.
Stromal cells possess a fundamental yet often underestimated role in maintaining tissue homeostasis and influencing immune responses during health and disease.
Our goal is to understand the intricate molecular mechanisms through which microbes modulate the function of stromal cells, acting as intermediaries between microbes and immunity. This comprehension offers the potential to capitalize on therapeutic interventions that target stromal cells and the microbiota.
To achieve this, we will employ comprehensive strategies like single-cell transcriptomics, spatial transcriptomics, metagenomics, and mouse/bacterial genetics to study highly controlled gnotobiotic model systems and human samples.